Key result
Functional nitric oxide synthase is absolutely required for endothelin-stimulated migration of endothelial cells via the ETB receptor.
This preclinical study demonstrates that nitric oxide synthesis is absolutely required for endothelin-stimulated migration of endothelial cells via the ETB receptor.
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Hypothesis-generating in animal models; human validation required before considering ETB-NOS modulation in vascular disease.
Noiri et al. (1997) studied Endothelial cell migration. Endothelins 1 and 3, IRL-1620 vs. ETB receptor antagonism, NO synthase inhibition was evaluated on Endothelial cell migration. Functional nitric oxide synthase is absolutely required for endothelin-stimulated migration of endothelial cells via the ETB receptor.
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