Key result
Medical management of asymptomatic chronic aortic regurgitation resulted in functional deterioration in 60% of patients at 24 months, while surgical valve replacement reversed this decline.
Why the study?
Does aortic valve replacement improve left ventricular function compared to medical therapy in patients with chronic aortic regurgitation?
Population
67 patients with chronic aortic regurgitation
Comparison
Aortic valve replacement (surgical treatment) vs Medical treatment
Design
Cohort
Follow-up
Up to 24 months for medical group, 15 months…
Authors
Loading...
May support earlier AVR consideration in asymptomatic AR with declining function; leaves open confirmation by randomized trials.
Cohort (n=67)
Does aortic valve replacement improve left ventricular function compared to medical therapy in patients with chronic aortic regurgitation?
Serial rest-exercise radionuclide angiography suggests that asymptomatic patients with chronic aortic regurgitation should be recommended for surgery when rest LVEF is <50% and functional reserve is abnormal.
Lumia et al. (1985) conducted a cohort in Chronic aortic regurgitation (n=67). Aortic valve replacement (surgical treatment) vs. Medical treatment was evaluated on Change in resting and postexercise left ventricular ejection fraction and functional reserve. Medical management of asymptomatic chronic aortic regurgitation resulted in functional deterioration in 60% of patients at 24 months, while surgical valve replacement reversed this decline.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: