March 1, 1980Circulation
Observations on the optimum time for operative intervention for aortic regurgitation. I. Evaluation of the results of aortic valve replacement in symptomatic patients.
Key result
Preoperative LV end-systolic dimension >55 mm and fractional shortening <25% identified patients at high risk for operative or late CHF death after aortic valve replacement (69% vs 6.25%, p<0.01).
Why the study?
Do preoperative echocardiographic parameters predict operative and late mortality in symptomatic patients undergoing aortic valve replacement for isolated aortic regurgitation?
Population
50 consecutive symptomatic patients undergoing aortic valve replacement for isolated aortic regurgitation
Design
Cohort
Follow-up
up to 43 months
Authors
Discussion
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Member takes
Implication
LV dilatation is universal in severe AR; supports serial echo monitoring but leaves open optimal surgical thresholds.
Study Design
Type
Cohort (n=50)
Structured PICO
Do preoperative echocardiographic parameters predict operative and late mortality in symptomatic patients undergoing aortic valve replacement for isolated aortic regurgitation?
P
Population
50 symptomatic patients undergoing aortic valve replacement for isolated aortic regurgitation, followed for 5 to 43 months.
E
Exposure
Aortic valve replacement
O
Outcome
Operative death and late death from congestive heart failurehard clinical
Main Result
Absolute Event Rate: 69% vs 6.25%
p-value: p=<0.01
Preoperative echocardiography identifying LV end-systolic dimension >55 mm and fractional shortening <25% strongly predicts poor survival after aortic valve replacement for aortic regurgitation.
Cite This Study
Henry et al. (1980) conducted a cohort in Isolated aortic regurgitation (n=50). Preoperative LV end-systolic dimension > 55 mm and fractional shortening < 25% vs. LV end-systolic dimension < 55 mm was evaluated on Operative or late death from congestive heart failure (p=<0.01). Preoperative LV end-systolic dimension >55 mm and fractional shortening <25% identified patients at high risk for operative or late CHF death after aortic valve replacement (69% vs 6.25%, p<0.01).