Key result
Reduced preoperative LVEF (<50%) before aortic valve replacement for chronic aortic regurgitation was linked to lower 10-year overall survival compared to preserved LVEF (80.1% vs 87.3%; P=0.036).
Why the study?
To evaluate echocardiographic prognostic factors associated with improved LV systolic function after aortic valve replacement and compare long-term outcomes in chronic aortic regurgitation patients with versus without LV dysfunction.
Does preoperative LVEF and early diastolic transmitral flow velocity/mitral annular tissue velocity ratio predict long-term survival and LV function improvement after aortic valve replacement in patients with chronic aortic regurgitation?
Population
280 patients undergoing aortic valve replacement for chronic aortic regurgitation
Comparison
Preoperative LVEF <50% (N=80) vs LVEF >=50% (N=200)
Design
Observational cohort study
Follow-up
Median 104.8 months
Authors
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Preoperative E/e′ may refine risk stratification before AVR in chronic AR; leaves open whether it should guide surgical timing in prospective cohorts.
Cohort (n=280)
Does preoperative LVEF and early diastolic transmitral flow velocity/mitral annular tissue velocity ratio predict long-term survival and LV function improvement after aortic valve replacement in patients with chronic aortic regurgitation?
Absolute Event Rate: 80.1% vs 87.3%
p-value: p=0.036
In patients undergoing aortic valve replacement for chronic aortic regurgitation, preoperative LV dysfunction is associated with worse long-term survival, and preoperative early diastolic transmitral flow velocity/mitral annular tissue velocity ratio is a strong predictor of postoperative LVEF recovery and survival.
Kim et al. (2020) conducted a cohort in Chronic aortic regurgitation (n=280). Reduced LV systolic function (LVEF <50%) vs. Preserved LV systolic function (LVEF ≥50%) was evaluated on Overall survival at postoperative 10 years (p=0.036). Reduced preoperative LVEF (<50%) before aortic valve replacement for chronic aortic regurgitation was linked to lower 10-year overall survival compared to preserved LVEF (80.1% vs 87.3%; P=0.036).
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