Key result
Sera from patients with rheumatoid arthritis (7.7% of 52) and systemic lupus erythematosus (26% of 27) suppressed mixed leukocyte culture reactivity, correlating with lymphocytotoxic antibodies.
Population
Sera and IgG fractions from normal subjects, 52 patients with rheumatoid arthritis, and 27 patients with…
Comparison
Addition of sera and IgG fractions to mixed… vs Sera and IgG fractions from normal subjects
Design
Preclinical
Authors
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Should not change RA or SLE management; leaves open whether lymphocytotoxic antibodies modulate immunity in vivo.
Sera and IgG fractions from a subset of patients with RA and SLE suppress mixed leukocyte culture reactivity, an effect that correlates with lymphocytotoxic antibodies.
Williams et al. (1973) studied Rheumatoid arthritis and systemic lupus erythematosus (n=79). Sera and IgG fractions vs. Normal subjects sera was evaluated on Suppression of mixed leukocyte culture (MLC) reactivity. Sera from patients with rheumatoid arthritis (7.7% of 52) and systemic lupus erythematosus (26% of 27) suppressed mixed leukocyte culture reactivity, correlating with lymphocytotoxic antibodies.
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