Sera from patients with rheumatoid arthritis (7.7% of 52) and systemic lupus erythematosus (26% of 27) suppressed mixed leukocyte culture reactivity, correlating with lymphocytotoxic antibodies.
Sera and IgG fractions from a subset of patients with RA and SLE suppress mixed leukocyte culture reactivity, an effect that correlates with lymphocytotoxic antibodies.
Abstract Sera and IgG fractions from normal subjects as well as patients with rheumatoid arthritis and systemic lupus erythematosus were added to mixed leukocyte reactions (MLC) in an attempt to study the effects on cell‐to‐cell interactions in such systems. Seven and seven‐tenths percent of 52 RA sera and 26% of 27 SLE sera showed suppression of MLC reactivity. MLC suppression appeared to be localized to IgG serum fractions separated by DEAE chromatography. This suppressive effect showed a strong correlation with presence of lymphocytotoxic antibody in individual sera.
Williams et al. (Sat,) conducted a other in Rheumatoid arthritis and systemic lupus erythematosus (n=79). Sera and IgG fractions vs. Normal subjects sera was evaluated on Suppression of mixed leukocyte culture (MLC) reactivity. Sera from patients with rheumatoid arthritis (7.7% of 52) and systemic lupus erythematosus (26% of 27) suppressed mixed leukocyte culture reactivity, correlating with lymphocytotoxic antibodies.