Periorbital Edema as the Initial Presentation of T-Cell Prolymphocytic Leukemia

In Brief A 57-year-old woman presented with a history of progressive bilateral upper and lower eyelid edema. Laboratory tests revealed T-cell prolymphocytic leukemia. Despite systemic treatment, she died 2 weeks after presentation. This life-threatening disorder should be added to the differential diagnosis of eyelid edema. Progressive periorbital edema was the initial clinical finding of T-cell prolymphocytic leukemia.