Management of High-Risk Populations with Locally Advanced Prostate Cancer

Learning Objectives After completing this course, the reader will be able to: Recognize the clinical and pathological characteristics of a prostate tumor that is at high risk of having spread beyond the gland. Be familiar with novel markers for detection of high-risk prostate cancers. Explain the management strategy for high-risk prostate cancer. Access and take the CME test online and receive one hour of AMA PRA category 1 credit at CME.TheOncologist.com Prostate cancer that extends beyond the confines of the prostatic gland on clinical and/or radiographic assessment, without evidence of lymph node or distant metastases, is regarded as locally advanced. The locally advanced prostate cancer patient population consists of a heterogeneous group of men, some of whom have tumors that may be amenable to primary curative intent with local definitive therapy associated with acceptable long-term cancer control rates. In order to optimally manage this group of patients, it is important to be able to recognize who is at a high risk of tumor recurrence after primary local therapy. In this brief review, we discuss the factors that contribute to the prediction of high risk in populations with locally advanced disease and the treatment options available.