Key result
In actomyosin sliding, different cardiac isomyosins (V1 and V3) mechanically interact in a dynamic manner that produces a sigmoid relation between mixing ratio and sliding velocity.
In vitro actomyosin sliding velocity exhibits a sigmoid relationship with the ratio of V1 to V3 isomyosins, indicating a dynamic mechanical interaction between coexisting isomyosins.
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Does not inform clinical management; leaves open whether isomyosin interactions regulate contractility in intact myocardium.
Sata et al. (1993) studied Cardiac isomyosin heterogeneity. V1 and V3 isomyosin mixtures vs. pPDM-treated V1 myosin was evaluated on ATPase activity and sliding velocity of actin-myosin. In actomyosin sliding, different cardiac isomyosins (V1 and V3) mechanically interact in a dynamic manner that produces a sigmoid relation between mixing ratio and sliding velocity.
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