Isolation and Characterization of Myosin and Two Myosin Fragments from Human Blood Platelets
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Population
Human blood platelets (1- to 5-days-old concentrates obtained from the NIH Blood Bank)
Comparison
Isolation and characterization of platelet… vs Rabbit skeletal-muscle myosin and actin
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports myosin-based platelet contraction mechanisms; leaves open therapeutic targeting in human thrombosis.
Structured PICO
P
Population
Human blood platelets (1- to 5-days-old concentrates obtained from the NIH Blood Bank)
I
Intervention
Isolation and characterization of platelet myosin and its fragments (head and rod) using SDS-polyacrylamide gel electrophoresis, ATPase assay, actin binding studies, and electron microscopy
C
Comparator
Rabbit skeletal-muscle myosin and actin
O
Outcome
Biochemical and structural characterization (molecular weight, ATPase activity, actin binding, and filament formation)surrogate
Human platelet myosin and its fragments share significant structural and functional properties with muscle myosin, supporting a common molecular basis for platelet contraction.
Cite This Study
Adelstein et al. (1971) studied this question.
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