Research Status of Traditional Chinese Medicine in the Treatment of Chronic Atrophic Gastritis Based on the PI3K/Akt Signaling Pathway

本文探讨了基于PI3K/Akt信号通路的中医治疗慢性萎缩性胃炎(CAG)的研究现状。CAG是一种胃黏膜上皮受损导致腺体减少的慢性疾病，与胃癌前病变密切相关。现代医学对该病尚无特效疗法，而中医通过多靶点、多途径调控PI3K/Akt信号通路，能够阻断CAG进展并延缓炎–癌转化。文章综述了PI3K/Akt信号通路在CAG中的作用机制，包括调控炎症反应、细胞增殖与凋亡等，并总结了多种中药单体和汤剂对PI3K/Akt通路的干预效果，为临床治疗及药物研发提供了参考。This paper explores the current research status of traditional Chinese medicine (TCM) in treating chronic atrophic gastritis (CAG) based on the PI3K/Akt signaling pathway. CAG is a chronic disease characterized by damage to the gastric mucosal epithelium leading to glandular reduction and is closely associated with precancerous gastric lesions. Modern medicine lacks specific therapies for this condition, whereas TCM can regulate the PI3K/Akt signaling pathway through multiple targets and pathways, thereby blocking CAG progression and delaying the inflammation-cancer transformation. The article reviews the mechanism of the PI3K/Akt signaling pathway in CAG, including its regulation of inflammatory responses, cell proliferation, and apoptosis, and summarizes the intervention effects of various TCM monomers and decoctions on the PI3K/Akt pathway, providing references for clinical treatment and drug development.