What question did this study set out to answer?

To characterize the evolutionary trajectories and clonal dynamics of multiple myeloma across the disease course in patients with standard-risk versus high-risk cytogenetics.

April 13, 2012BloodOpen Access

Clonal competition with alternating dominance in multiple myeloma

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To characterize the evolutionary trajectories and clonal dynamics of multiple myeloma across the disease course in patients with standard-risk versus high-risk cytogenetics.
Conducted serial genomic analysis on longitudinal tumor samples collected across the disease course of 28 patients with multiple myeloma.
Profiled one high-risk patient across 7 distinct time points to map clonal shifts in response to sequential therapies.
Modeled subclonal competition and therapeutic selection pressure in vivo using the Vk*MYC genetically engineered mouse model of myeloma.
Genomes of standard-risk myeloma patients exhibited minimal changes over time, whereas cytogenetically high-risk patients showed significantly increased genomic alterations.
Identified three distinct temporal tumor patterns: genetically stable, linearly evolving, and heterogeneous mixtures characterized by shifting dominant clones.
Demonstrated that competing subclones can alternate dominance back and forth across therapeutic interventions before one clone undergoes dramatic linear evolution.

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Implication

Serial genomic analysis reveals alternating subclone dominance and dynamic clonal evolution in multiple myeloma, highlighting distinct evolutionary patterns between risk groups.

Cite This Study

Keats et al. (2012) studied this question.

synapsesocial.com/papers/6a0cd36e3239dcc1e46263fb https://doi.org/10.1182/blood-2012-01-405985

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Implication

Serial genomic analysis reveals alternating subclone dominance and dynamic clonal evolution in multiple myeloma, highlighting distinct evolutionary patterns between risk groups.

Clonal competition with alternating dominance in multiple myeloma

Key Points

Discussion

Implication

Cite This Study

Clonal competition with alternating dominance in multiple myeloma

Key Points

Discussion

Implication

Cite This Study

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