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June 1, 1983The Journal of PhysiologyOpen Access

Temperature‐dependent transitions in isometric contractions of rat muscle.

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Why the study?

Does temperature variation affect tetanic tension development in rat fast-twitch and slow-twitch muscles?

Population

Rat extensor digitorum longus (fast-twitch) and soleus (slow-twitch) muscles in vitro

Comparison

Temperature variation vs Baseline temperature or different temperature…

Design

Preclinical

Key result

Cooling rat muscles below 20°C resulted in a marked depression of tetanic tension, with activation energy estimates below 21°C being twice as high as those above 24°C.

Authors

KRK. W. RanatungaSWSteven R. Wylie

Discussion

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Overview

Cautions against direct clinical extrapolation from rat models; leaves open human muscle temperature effects pending further study.

Key Points

  • To investigate the effects of temperatures between 10 °C and 35 °C on tetanic tension development and relaxation kinetics in fast-twitch and slow-twitch rat muscles.
  • Extensor digitorum longus (fast-twitch) and soleus (slow-twitch) muscles from rats were isolated and evaluated in vitro using direct electrical stimulation across a 10 °C to 35 °C range.
  • Temperature dependence was quantified by calculating Arrhenius plots and activation energy estimates for tension development and relaxation rates.
  • Maximum tetanic tension decreased slightly between 35 °C and 25 °C, but cooling below 20 °C caused a marked depression in tension that was consistent across both muscle types.
  • Arrhenius plots demonstrated a biphasic transition with higher thermal sensitivity below approximately 25 °C, yielding activation energies below 21 °C that were roughly twice as high as those above 24 °C.

Structured PICO

Does temperature variation affect tetanic tension development in rat fast-twitch and slow-twitch muscles?

P
Population
Rat extensor digitorum longus (fast-twitch) and soleus (slow-twitch) muscles in vitro
I
Intervention
Temperature variation (cooling from 35 to 10 degrees C)
C
Comparator
Baseline temperature (35 degrees C) or different temperature ranges
O
Outcome
Tetanic tension development and relaxation ratesurrogate

Cooling below 25 degrees C significantly depresses tetanic tension and alters the temperature dependence of tension development and relaxation in rat skeletal muscle.

Cite This Study

Ranatunga et al. (1983) studied Normal rat muscle physiology. Temperature reduction was evaluated on Tetanic tension development and relaxation. Cooling rat muscles below 20°C resulted in a marked depression of tetanic tension, with activation energy estimates below 21°C being twice as high as those above 24°C.

synapsesocial.com/papers/6a0cd3f063ecdfd686625a34https://doi.org/10.1113/jphysiol.1983.sp014704
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