What does this research mean for the field?

Fast- and slow-twitch skeletal muscle fibers exhibit distinct calcium activation kinetics and temperature dependencies, with fast-twitch fibers requiring more calcium ions for activation and showing decreased calcium sensitivity as temperature increases from 5 to 25 degrees C. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore the effects of temperature on calcium-activated force responses in rat fast- and slow-twitch muscle fibres.

August 1, 1981The Journal of PhysiologyOpen Access

Calcium‐activated force responses in fast‐ and slow‐twitch skinned muscle fibres of the rat at different temperatures.

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Population

Mechanically skinned fibres of rat skeletal muscles (extensor digitorum longus and soleus)

Comparison

Sudden changes in Ca2+ concentration at… vs Different temperatures and muscle fibre types

Design

Preclinical

Authors

DSD. George StephensonLa Trobe University DWDavid A. WilliamsForest Institute

Discussion

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Implication

Temperature effects on rat fiber force require cautious interpretation at non-physiological conditions; leaves open translation to human cardiac contractility.

Key Points

This research aims to explore the effects of temperature on calcium-activated force responses in rat fast- and slow-twitch muscle fibres.
Measured force responses in skinned fibres from rat skeletal muscles at temperatures between 3-35°C.
Analyzed force-[Ca2+] relations and Ca2+ kinetics for slow- and fast-twitch fibres.
Compared rates of relaxation and Ca2+ sensitivity changes with temperature variations.
Fast-twitch fibres showed a decrease in Ca2+ sensitivity by a factor of 2 when temperature increased from 5 to 25°C (p<0.05).
Slow-twitch fibres demonstrated a significantly slower rate of relaxation at 5°C compared to fast-twitch fibres.
Oscillatory processes in slow-twitch fibres increased with temperature, with maximum force dependence noted up to 25°C.

Structured PICO

Population

Mechanically skinned fibres of rat skeletal muscles (extensor digitorum longus and soleus)

Intervention

Sudden changes in Ca2+ concentration at different temperatures (3-35 degrees C)

Comparator

Different temperatures and muscle fibre types (fast- vs slow-twitch)

Outcome

Force responses and Ca2+ sensitivitysurrogate

Temperature significantly affects maximum Ca2+-activated force and Ca2+ sensitivity differently in fast- and slow-twitch rat skeletal muscle fibers.

Cite This Study

Stephenson et al. (1981) studied this question.

synapsesocial.com/papers/6a15fc60a215942ca9e3f4e2 https://doi.org/10.1113/jphysiol.1981.sp013825

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Implication

Temperature effects on rat fiber force require cautious interpretation at non-physiological conditions; leaves open translation to human cardiac contractility.

Calcium‐activated force responses in fast‐ and slow‐twitch skinned muscle fibres of the rat at different temperatures.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Calcium‐activated force responses in fast‐ and slow‐twitch skinned muscle fibres of the rat at different temperatures.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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