Key result
Vitamin-D-binding protein and gelsolin formed tight complexes with actin (Kd ~10 nm), with the DBP-actin complex forming preferentially when both were added simultaneously to G-actin.
Population
In vitro model using fluorescent 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole-actin or…
Design
Preclinical
Authors
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Remains preclinical; leaves open DBP-gelsolin competition in actin scavenging in vivo.
Effect estimate: Kd ~10 nm
This basic science study elucidates the individual and competitive interactions of serum vitamin-D-binding protein and plasma gelsolin with actin in solution.
Coué et al. (1986) studied this question. Vitamin-D-binding protein (DBP) and plasma gelsolin was evaluated on Interaction with actin (Kd ~10 nm). Vitamin-D-binding protein and gelsolin formed tight complexes with actin (Kd ~10 nm), with the DBP-actin complex forming preferentially when both were added simultaneously to G-actin.
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