Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 15, 2007Clinical Cancer Research

CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo

View Full Paper
Ask AI
Bookmark
Share

Authors

ATArchie TseBrunswick (United States)KRKatherine G. RendahlNovartis (Switzerland)TSTahir SheikhBoston University

Discussion

Loading...

Member takes

Overview

Key Points

Key points are not available for this paper at this time.

Cite This Study

Tse et al. (2007) studied this question.

synapsesocial.com/papers/6a0cd598c6fb28010734cc86https://doi.org/10.1158/1078-0432.ccr-06-1424
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of Chk1 by CEP-3891 Accelerates Mitotic Nuclear Fragmentation in Response to Ionizing Radiation2004 · 99 citations
  2. 2Abrogation of the S Phase DNA Damage Checkpoint Results in S Phase Progression or Premature Mitosis Depending on the Concentration of 7-Hydroxystaurosporine and the Kinetics of Cdc25C Activation2002 · 104 citations
  3. 3ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk12001 · 1,073 citations
  4. 4Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases2005 · 164 citations