Key result
In vivo cardiac dysfunctions observed at low temperatures in rats were attributable to shifts in temperature kinetics of enzyme systems at 20 to 21 C.
Why the study?
How does deep hypothermia affect heart rate, electrocardiogram, and myocardial oxidations in rats?
Population
Rats (in vivo deep hypothermia model and in vitro myocardial metabolic activity assays)
Comparison
Temperature changes vs Different temperature levels
Design
Preclinical
Authors
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Rat model implicates enzyme kinetic shifts at 20–21°C in hypothermic dysfunction; leaves open clinical translation.
How does deep hypothermia affect heart rate, electrocardiogram, and myocardial oxidations in rats?
Cardiac dysfunctions during deep hypothermia in rats appear to be caused by shifts in the temperature kinetics of myocardial enzyme systems around 20-21 C.
John P. Hannon (1958) studied Deep hypothermia. Deep hypothermia / temperature changes was evaluated on Sequential changes in body temperature, heart rate, electrocardiogram, and in vitro myocardial metabolic activity. In vivo cardiac dysfunctions observed at low temperatures in rats were attributable to shifts in temperature kinetics of enzyme systems at 20 to 21 C.
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