What question did this study set out to answer?

To evaluate the in vivo physiological necessity of interleukin 7 (IL-7) during murine B and T cell lymphopoiesis.

July 1, 1993The Journal of Experimental MedicineOpen Access

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

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To evaluate the in vivo physiological necessity of interleukin 7 (IL-7) during murine B and T cell lymphopoiesis.
Administered a neutralizing anti-interleukin 7 monoclonal antibody to mice in vivo.
Assessed lymphocyte development and cell population dynamics across bone marrow, peripheral lymphoid tissues, and the thymus.
Completely arrested marrow B lymphopoiesis from the pro-B cell developmental stage onward following anti-IL-7 antibody administration.
Demonstrated that both conventional and B-1 peripheral B lineages derive from IL-7-dependent marrow precursors.
Substantially reduced total thymus cellularity, impairing all major thymic subpopulations.

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Implication

Animal study reveals that neutralizing interleukin 7 blocks early B and T lymphocyte development in mice, indicating an essential role for the cytokine in ongoing lymphopoiesis.

Cite This Study

Grabstein et al. (1993) studied this question.

synapsesocial.com/papers/6a0cd75ceff1ba4410c40265 https://doi.org/10.1084/jem.178.1.257

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Implication

Animal study reveals that neutralizing interleukin 7 blocks early B and T lymphocyte development in mice, indicating an essential role for the cytokine in ongoing lymphopoiesis.

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

Key Points

Discussion

Implication

Cite This Study

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

Key Points

Discussion

Implication

Cite This Study

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