What question did this study set out to answer?

To determine the global prevalence and type distribution of human papillomavirus (HPV) across anatomic sites in head and neck squamous cell carcinomas (HNSCC).

February 1, 2005Cancer Epidemiology Biomarkers & Prevention

Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review

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Authors

AKAimée R. KreimerNational Institutes of Health GCGary M. CliffordCentre international de recherche sur le cancer PBPeter BoyleBroad Institute

Discussion

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Implication

Systematic review reveals HPV infection in 25.9% of head and neck squamous cell carcinomas worldwide, indicating strong anatomical predilection for HPV16 in the oropharynx.

Key Points

To determine the global prevalence and type distribution of human papillomavirus (HPV) across anatomic sites in head and neck squamous cell carcinomas (HNSCC).
Systematically reviewed 60 studies comprising 5,046 HNSCC biopsy specimens that used PCR-based assays to detect and genotype HPV.
Evaluated HPV prevalence and genotype distributions across anatomic sites (oropharyngeal, oral, and laryngeal), geographic regions, and sample sizes.
Overall HPV prevalence was 25.9% (95% CI, 24.7–27.2%), with significantly higher prevalence in oropharyngeal SCCs (35.6% of 969; 95% CI, 32.6–38.7%) than oral SCCs (23.5% of 2,642; 95% CI, 21.9–25.1%) or laryngeal SCCs (24.0% of 1,435; 95% CI, 21.8–26.3%).
HPV16 accounted for 86.7% (95% CI, 82.6–90.1%) of HPV-positive oropharyngeal SCCs versus 68.2% (95% CI, 64.4–71.9%) in oral and 69.2% (95% CI, 64.0–74.0%) in laryngeal SCCs, whereas HPV18 was rare in the oropharynx (2.8%; 95% CI, 1.3–5.3%).
Site-specific HPV prevalence was higher in studies from North America than in Europe and Asia, while non-HPV16/18 oncogenic types were rarely detected across all sites.

Cite This Study

Kreimer et al. (2005) studied this question.

synapsesocial.com/papers/6a0ce086df69d124d80265ae https://doi.org/10.1158/1055-9965.epi-04-0551

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Implication

Systematic review reveals HPV infection in 25.9% of head and neck squamous cell carcinomas worldwide, indicating strong anatomical predilection for HPV16 in the oropharynx.

Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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