HIV-1 Protease Drug-resistant Mutations and Inhibitor Binding Mechanism: A Review on Hybrid Quantum Mechanics/Molecular Mechanics Approach

Neha Kumari, Gurpreet Bamrah, Amrita Biswas and Saurabh Srivastava HIV-1 (Human immunodeficiency virus type one) protease (PR) is a decisive enzyme for the replication of HIV-1. It is important in the progression of acquired immunodeficiency syndrome (AIDS). The viral enzyme integrase is required for HIV-1 replication because it permits viral DNA to be integrated into the DNA of the host cell.