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Inhibitory constants (Ki) between 5 and 35 nM were derived (under different conditions of pH and ionic strength) for the interaction of HIV-1 proteinase with acetyl-pepstatin and H-261, two characteristic inhibitors of aspartic proteinases. Thus this enzyme, essential for replication of the AIDS virus, may be classified unequivocally as belonging to this proteinase family.
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Anthony D. Richards
Woodwell Climate Research Center
R. M. Roberts
National Agricultural Statistics Service
Ben M. Dunn
Technion – Israel Institute of Technology
FEBS Letters
La Roche College
University of Florida Health Science Center
Johnson & Wales University
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Richards et al. (Mon,) studied this question.
synapsesocial.com/papers/6a0ce224edb32e8d900263f7 — DOI: https://doi.org/10.1016/0014-5793(89)81251-7
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