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June 1, 1998Annual Review of Biophysics and Biomolecular Structure

INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design

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Authors

AWAlexander WlodawerNational Institutes of HealthJVJiřı́ VondrášekCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

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Wlodawer et al. (1998) studied this question.

synapsesocial.com/papers/6a0ce2e17aad2cc6fd1f5e44https://doi.org/10.1146/annurev.biophys.27.1.249
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes1991 · 126 citations
  2. 2STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE1993 · 828 citations
  3. 3Design and synthesis of HIV protease inhibitors. Variations of the carboxyterminus of the HIV protease inhibitor L-682,6791991 · 41 citations
  4. 4A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site1995 · 232 citations
  5. 5X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.1990 · 276 citations