What question did this study set out to answer?

To examine how the conditional loss of the tumor suppressor HIC1 influences breast cancer progression and communication between cancer cells and the surrounding microenvironment.

September 11, 2018Journal of Clinical InvestigationOpen Access

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk

View Full Paper

Ask AI

Bookmark

To examine how the conditional loss of the tumor suppressor HIC1 influences breast cancer progression and communication between cancer cells and the surrounding microenvironment.
Generated conditional knockout mouse models with HIC1 deleted specifically in the mammary gland to evaluate early tumor transformation.
Investigated molecular crosstalk between HIC1-deficient breast cancer cells and mammary fibroblasts, focusing on chemokine secretion and downstream receptor signaling pathways.
HIC1 deletion prompted breast cancer cells to secrete CXCL14, which bound GPR85 on stromal fibroblasts and activated them through ERK1/2, Akt, and neddylation pathways.
Activated fibroblasts stimulated epithelial-mesenchymal transition and accelerated tumor progression through the CCL17/CCR4 signaling axis, confirming a pro-tumorigenic HIC1-CXCL14-CCL17 feedback loop.

Authors

YWYingying WangShandong University XWXiaoling WengShanghai Jiao Tong University LWLuoyang WangQingdao University

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Preclinical study demonstrates HIC1 deletion accelerates breast cancer progression in mouse models, highlighting therapeutic microenvironment targets.

Cite This Study

Wang et al. (2018) studied this question.

synapsesocial.com/papers/6a0ce723a1eb61793c026f3e https://doi.org/10.1172/jci99974

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study demonstrates HIC1 deletion accelerates breast cancer progression in mouse models, highlighting therapeutic microenvironment targets.

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk

Key Points

Discussion

Implication

Cite This Study

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider