What question did this study set out to answer?

To review the structural and functional domains of the androgen receptor and clarify their roles in prostate cancer growth following the failure of androgen ablation therapy.

July 18, 2007Molecular Endocrinology

Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer

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Authors

SDScott M. DehmUniversity of Minnesota DTDonald J. TindallMayo Clinic

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Implication

Narrative review reveals mechanisms of androgen receptor activation in hormone-refractory prostate cancer, highlighting targets for novel receptor-directed therapies.

Key Points

To review the structural and functional domains of the androgen receptor and clarify their roles in prostate cancer growth following the failure of androgen ablation therapy.
Synthesized molecular and biochemical literature regarding the domain structure and activation mechanisms of the androgen receptor protein.
Evaluated clinical and experimental evidence on how prostate tumors transition to androgen depletion-independent growth while maintaining receptor activity.
Prostate tumors recurring after androgen ablation therapy maintain reliance on functional androgen receptor activation for continued proliferation.
Structural mapping reveals discrete functional domains within the androgen receptor that govern hormone-independent activation and disease progression.

Cite This Study

Dehm et al. (2007) studied this question.

synapsesocial.com/papers/6a0cea48d2f99fbc58fc0bd4 https://doi.org/10.1210/me.2007-0223

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Implication

Narrative review reveals mechanisms of androgen receptor activation in hormone-refractory prostate cancer, highlighting targets for novel receptor-directed therapies.

Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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