What does this research mean for the field?

Categorical definitions of ARDS based solely on hypoxemia severity fail to accurately capture individual mortality risk, which is significantly better predicted by a multivariable approach incorporating nonpulmonary physiologic risk factors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1994

Evaluation of Definitions for Adult Respiratory Distress Syndrome

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Abstract

We conducted a cohort study of 423 intensive care unit (ICU) admissions with a primary clinical diagnosis of acute respiratory failure, a PaO2/FIO2 on ICU admission of 90% in both groups. We conclude that ARDS is a complex clinical entity with a variety of pulmonary and nonpulmonary risk factors for both its development and its prognosis. Current and proposed categorical definitions based on the severity of hypoxemia result in a wide distribution of individual patient risks. Use of these findings in the design and conduct of future clinical trials would improve the evaluation of new therapies.

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Cite This Study

Knaus et al. (Mon,) studied this question.

synapsesocial.com/papers/6a0cefb4be0a9f67ad7c77c7 https://doi.org/https://doi.org/10.1164/ajrccm.150.2.8049808

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