Key result
The c-Mpl intracellular domain contains at least two distinct regions for signal transduction, with the proximal 63 amino acids mediating JAK-STAT activation and the C-terminus required for Shc phosphorylation.
Population
Interleukin 3-dependent cell line Ba/F3 and a megakaryocytic cell line
Design
Preclinical
Authors
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No immediate clinical implications for TPO agonists; leaves open selective pathway research in models.
The c-Mpl receptor utilizes at least two distinct intracellular regions to mediate signal transduction via the JAK-STAT and Ras pathways.
Gurney et al. (1995) studied Signal transduction by c-Mpl. Chimeric receptor (extracellular domain of human growth hormone receptor and intracellular domain of c-Mpl) was evaluated on Signal transduction pathways (JAK-STAT and Shc phosphorylation). The c-Mpl intracellular domain contains at least two distinct regions for signal transduction, with the proximal 63 amino acids mediating JAK-STAT activation and the C-terminus required for Shc phosphorylation.
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