The strong influence exerted by the greatly varying normal gastrointestinal functions on the therapeutic value of a controlled-release single-unit dose is elucidated by a review of the literature. In this setting, the multiple-units dose comprising hundreds of mini-depots presents a highly preferable alternative which is due to a greater predictability and reproducibility of its therapeutic effect as well as a lowered risk of side effects.
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Bechgaard et al. (1978) studied this question.
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