Key result
In depolarized guinea pig myocardium, automatic activity development is associated with a time-dependent decrease in outward K+ current and an increase in background inward Ca2+/Na+ current.
Population
segments, 0.7-1.0 mm long, of guinea pig papillary muscles excised from the right ventricle
Design
Preclinical
Authors
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Extends basic mechanisms of automaticity in depolarized tissue; leaves open translation to human arrhythmias.
Automatic activity in depolarized guinea pig ventricular myocardium is driven by a time-dependent decrease in outward potassium current and an increase in background inward calcium/sodium current.
Imanishi et al. (1976) studied Depolarized guinea pig ventricular myocardium. Extracellular polarizing current pulses and ion concentration changes was evaluated on Characteristics and mechanisms of automatic activity (RAD). In depolarized guinea pig myocardium, automatic activity development is associated with a time-dependent decrease in outward K+ current and an increase in background inward Ca2+/Na+ current.
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