Key result
The definition of severe pulmonary hypertension has evolved over time, with 2015 guidelines defining it by a mean pulmonary artery pressure >35 mmHg or ≥25 mmHg with a cardiac index <2.5 L/min.
Population
Patients with pulmonary hypertension associated with lung diseases and/or hypoxia
Design
Editorial
Authors
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This viewpoint critiques the evolving definitions of severe pulmonary hypertension, particularly the use of pulmonary vascular resistance.
This viewpoint critiques the evolving definitions of severe pulmonary hypertension, particularly the use of pulmonary vascular resistance.
Naeije et al. (2025) conducted an editorial in Pulmonary hypertension associated with lung diseases and/or hypoxia. The definition of severe pulmonary hypertension has evolved over time, with 2015 guidelines defining it by a mean pulmonary artery pressure >35 mmHg or ≥25 mmHg with a cardiac index <2.5 L/min.
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