April 25, 2005Circulation
Late Gadolinium Enhancement Cardiovascular Magnetic Resonance of the Systemic Right Ventricle in Adults With Previous Atrial Redirection Surgery for Transposition of the Great Arteries
Key result
Late gadolinium enhancement in the systemic right ventricle was present in 61% of patients and associated with a higher incidence of arrhythmia or syncope (40.9% vs 7.1%; P=0.03).
Why the study?
Does late gadolinium enhancement on CMR correlate with ventricular dysfunction and adverse clinical features in adults with previous atrial redirection surgery for transposition of the great arteries?
Population
36 consecutive adult patients after atrial redirection surgery for transposition of the great arteries
Design
Cross-sectional
Authors
Discussion
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Implication
May support arrhythmia risk stratification by LGE in systemic RV; hypothesis-generating and requires prospective validation before clinical adoption.
Study Design
Type
Observational (n=36)
Structured PICO
Does late gadolinium enhancement on CMR correlate with ventricular dysfunction and adverse clinical features in adults with previous atrial redirection surgery for transposition of the great arteries?
P
Population
36 consecutive adult patients (mean age, 27 years) after atrial redirection surgery for transposition of the great arteries
I
Intervention
Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR)
O
Outcome
Presence of LGE in the systemic RV and its relation to adverse clinical features (RV dysfunction, electrophysiological parameters, and clinical events)surrogate
Main Result
Absolute Event Rate: 40.9% vs 7.1%
p-value: p=0.03
LGE CMR reveals myocardial fibrosis in the systemic RV of patients after atrial redirection surgery, which correlates with ventricular dysfunction, electrophysiological abnormalities, and clinical events.
Cite This Study
Babu‐Narayan et al. (2005) conducted an observational in Transposition of the great arteries (n=36). Late gadolinium enhancement cardiovascular magnetic resonance vs. Patients without late gadolinium enhancement was evaluated on Incidence of documented arrhythmia and/or syncope (p=0.03). Late gadolinium enhancement in the systemic right ventricle was present in 61% of patients and associated with a higher incidence of arrhythmia or syncope (40.9% vs 7.1%; P=0.03).