Key result
In long QT syndrome, swimming-related cardiac events were exclusively associated with the LQT1 genotype (19/19), while auditory-related events were predominantly associated with LQT2 (5/6; p<0.001).
Why the study?
Do clinical and genetic profiles differ between LQTS patients whose cardiac events are triggered by loud noise versus swimming?
Population
195 patients with long QT syndrome who experienced an index cardiac event associated with a loud noise or…
Comparison
Index cardiac event associated with loud noise vs Index cardiac event associated with swimming…
Design
Cohort
Authors
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May inform genotype-specific trigger counseling in LQTS; supports observational links but leaves prospective validation open.
Observational (n=195)
Do clinical and genetic profiles differ between LQTS patients whose cardiac events are triggered by loud noise versus swimming?
p-value: p=<0.001
Cardiac events triggered by swimming in LQTS patients are strongly linked to the LQT1 genotype, while those triggered by loud noises are linked to the LQT2 genotype, highlighting genotype-specific triggers.
Moss et al. (1999) conducted an observational in Long QT syndrome (n=195). Loud noise trigger vs. Swimming activity trigger was evaluated on Distribution of index cardiac events by genotype (p=<0.001). In long QT syndrome, swimming-related cardiac events were exclusively associated with the LQT1 genotype (19/19), while auditory-related events were predominantly associated with LQT2 (5/6; p<0.001).
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