Native T1 mapping and extracellular volume fraction for differentiation of myocardial diseases from normal CMR controls in routine clinical practice

Fig. 1. Details of the study population. CAD coronary artery disease, DCM dilated cardiomyopathy, HCM hypertrophic cardiomyopathy

Fig. 2. T1 mapping is displayed in color scale. A upper panels, native T1 and T1 enhanced; lower panels, native T1 and T1 enhanced with color scale. B upper panels, T1 map with color scale and region of interest. Mid-left ventricular short axis (Mid LV) native T1 mapping showed endocardial (blue line) and epicardial (red line) contours, as well as the region-of-interest for the calculation of the average myocardial T1 value. Lower panels, the subdivided 6 segments of mid-left ventricular short axis myocardium are represented, as follows: a mid anterior wall, b mid anteroseptal wall, c mid inferoseptal wall, d mid inferior wall, e mid inferolateral wall, and f mid anterolateral wall

Fig. 3. Comparison of native T1 values and ECV among myocardial diseases, coronary artery disease (CAD) and controls (DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy). A native T1 at septum, B native T1 at mid LV, C ECV using actual Hct at septum, D ECV using actual Hct at mid LV, E ECV using synthetic Hct at septum, F ECV using synthetic Hct at mid LV

Fig. 4. Receiver operating characteristic curve of native T1 and ECV for the diagnosis of amyloidosis, myocarditis, hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and coronary artery disease (CAD). AUC = area under the curve. A Native T1–septum, B Native T1–mid LV, C ECV actual Hct–septum, D ECV actual Hct–mid LV, E ECV synthetic Hct–septum and F ECV synthetic Hct–mid LV

Fig. 5. 95% Confidence interval (CI) box graph showing comparison of native T1 at mid LV and extracellular volume (ECV) using synthetic Hct at mid LV in the myocardial diseases, coronary artery disease (CAD), and control groups (DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy)(Horizontal dimension of each box indicates 95% CI of native T1, vertical dimension indicates 95% CI of ECV, mid-point indicates mean value of native T1 and ECV)

Fig. 6. Bland-Altman comparison of different methods for measuring native T1 and ECV. A mid LV and septum native T1, B mid LV and septum ECV with actual Hct, C mid LV and septum ECV with synthetic Hct, D mid LV ECV by actual Hct and synthetic Hct, E septum ECV by actual Hct and synthetic Hct