Key result
Review highlights key ARVC mimics including Brugada syndrome, athlete's heart, and cardiac sarcoidosis.
Why the study?
The diagnosis of ARVC can be challenging due to variable expressivity, incomplete penetrance, lack of specific diagnostic criteria, and multiple conditions that mimic its clinical phenotypes.
This review highlights the challenges in diagnosing ARVC and provides guidance on differentiating it from various mimicking conditions to prevent misdiagnosis.
Diagnostic vigilance required for ARVC mimics; leaves open prospective validation of differentiation criteria.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease, which is characterized by fibro-fatty replacement of predominantly the right ventricle (RV). The disease can result in ventricular tachyarrhythmias and sudden cardiac death. Our understanding of the pathophysiology and clinical expressivity of ARVC has been continuously evolving. The diagnosis can be challenging due to its variable expressivity, incomplete penetrance and the lack of specific diagnostic criteria. Idiopathic RV outflow tract tachycardia, Brugada Syndrome, athlete's heart, dilated cardiomyopathy, myocarditis, cardiac sarcoidosis, congenital aneurysms and diverticula may mimic clinical phenotypes of ARVC. This review aims to provide an update on the differential diagnosis of ARVC.
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Molitor et al. (2022) conducted a review in Arrhythmogenic right ventricular cardiomyopathy (ARVC). This review outlines the differential diagnosis of arrhythmogenic right ventricular cardiomyopathy, highlighting mimicking conditions such as Brugada Syndrome, athlete's heart, and cardiac sarcoidosis.
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