Experimental-mathematical modeling of EV71 strains in cell culture demonstrated that viral productivity and transmissibility, but not cytotoxicity, differ drastically among strains.
This study demonstrates the dynamics of nonenveloped virus replication in cell culture using mathematical modeling, showing strain-specific differences in viral productivity and transmissibility.
Enterovirus 71 (EV71) is the causative agent of hand-foot-and-mouth disease and can trigger neurological disorders. EV71 outbreaks are a major public health concern in Asia-Pacific countries. By performing experimental-mathematical investigation, we demonstrate here that viral productivity and transmissibility but not viral cytotoxicity are drastically different among EV71 strains and can be associated with their epidemiological backgrounds. This is the first report demonstrating the dynamics of nonenveloped virus replication in cell culture using mathematical modeling.
Fukuhara et al. (Thu,) conducted a other in Enterovirus 71 (EV71) infection. Mathematical modeling of EV71 strains was evaluated on Viral productivity, transmissibility, and cytotoxicity. Experimental-mathematical modeling of EV71 strains in cell culture demonstrated that viral productivity and transmissibility, but not cytotoxicity, differ drastically among strains.