Key result
A combination of pilsicainide, propranolol, and verapamil successfully prevented recurrent episodes of idiopathic ventricular fibrillation initiated by short-coupled ventricular premature beats.
Why the study?
Does the combination of pilsicainide, propranolol, and verapamil prevent idiopathic ventricular fibrillation initiated by short-coupled ventricular premature beats?
Case Report (n=1)
No
Does the combination of pilsicainide, propranolol, and verapamil prevent idiopathic ventricular fibrillation initiated by short-coupled ventricular premature beats?
A combination of pilsicainide, propranolol, and verapamil may be effective in preventing idiopathic ventricular fibrillation initiated by short-coupled ventricular premature beats.
May warrant consideration in refractory short-coupled VF; hypothesis-generating and requires prospective validation.
We report the case of a 38-year-old man who had idiopathic ventricular fibrillation (VF) which initiated by abnormally short-coupled ventricular premature beats. VF was successfully prevented by the combination of pilsicainide, propranolol, and verapamil. In particular, the effects of pilsicainide are assumed to exert an important effect in controlling this arrhythmia. Class Ic drugs may be effective for preventing VF initiated by short-coupled VPBs.
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Nakazato et al. (1996) conducted a case report in Idiopathic ventricular fibrillation (n=1). Pilsicainide, propranolol, and verapamil was evaluated on Prevention of ventricular fibrillation. A combination of pilsicainide, propranolol, and verapamil successfully prevented recurrent episodes of idiopathic ventricular fibrillation initiated by short-coupled ventricular premature beats.
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