Design
Review
Key result
A baroreflex-independent sympathetic control system and a central nervous system set point are proposed for the long-term regulation of mean arterial pressure and the pathogenesis of hypertension.
Authors
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Challenges baroreflex-centric hypertension models; leaves open CNS set-point validation before clinical consideration.
This review proposes a novel central nervous system 'set point' for long-term mean arterial pressure control, independent of the arterial baroreceptor reflex.
Osborn et al. (2005) conducted a review in Arterial pressure regulation. A baroreflex-independent sympathetic control system and a central nervous system set point are proposed for the long-term regulation of mean arterial pressure and the pathogenesis of hypertension.