Regular aerobic exercise modulates age‐associated declines in cardiovagal baroreflex sensitivity in healthy men
Key result
A 3-month aerobic exercise intervention increased cardiovagal baroreflex sensitivity by an average of 25% (P<0.05) in previously sedentary middle-aged and older healthy men.
Authors
Discussion
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Implication
Hypothesis-generating for exercise effects on baroreflex sensitivity; randomized trials needed before any practice change.
Key Points
- To determine the effects of habitual aerobic exercise and short-term exercise training on the age-associated decline in cardiovagal baroreflex sensitivity among healthy men.
- Evaluated cardiovagal baroreflex sensitivity via phase IV of Valsalva's manoeuvre in a cross-sectional cohort of 133 healthy men aged 18–79 years grouped as sedentary, moderately active, or endurance-trained.
- Conducted a 3-month prospective aerobic walking intervention in 13 previously sedentary middle-aged and older healthy men (mean age 56 ± 1 years).
- In sedentary men, cardiovagal baroreflex sensitivity was lower by approximately 33% in middle-aged and 60% in older groups compared with young men (P < 0.05), whereas exercising older men experienced only an approximate 30% reduction across age.
- Middle-aged and older men engaging in regular aerobic exercise exhibited 40% to 75% higher cardiovagal baroreflex sensitivity than their sedentary peers (P < 0.05).
- A 3-month aerobic walking intervention increased cardiovagal baroreflex sensitivity by an average of 25% (P < 0.05) in previously sedentary older men.
Study Design
Type
Cross-Sectional (n=146)
PICO
P
Population
Healthy men (n=146)
I
Intervention / Comparator
Regular aerobic exercise vs Sedentary lifestyle
O
Primary Outcome
Cardiovagal baroreflex sensitivity (BRS), p=<0.05
Main Result
p-value: p=<0.05
Cite This Study
Monahan et al. (2000) conducted a cross-sectional in Healthy men (n=146). Regular aerobic exercise vs. Sedentary lifestyle was evaluated on Cardiovagal baroreflex sensitivity (BRS) (p=<0.05). A 3-month aerobic exercise intervention increased cardiovagal baroreflex sensitivity by an average of 25% (P<0.05) in previously sedentary middle-aged and older healthy men.