John W. Finney, Roger E. Mitchell, Ruth C. Cronkite, Rudolph H. Moos, Methodological Issues in Estimating Main and Interactive Effects: Examples from Coping/Social Support and Stress Field, Journal of Health and Social Behavior, Vol. 25, No. 1 (Mar., 1984), pp. 85-98
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Finney et al. (1984) studied this question.