What question did this study set out to answer?

To identify clinical, echocardiographic, and biomarker mechanisms associated with early arrhythmia recurrence and progression to permanent atrial fibrillation in patients with short-lasting persistent atrial fibrillation.

January 10, 2012EP EuropaceOpen Access

Role of inflammation in early atrial fibrillation recurrence

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Why the study?

Are inflammatory markers like IL-6 associated with early atrial fibrillation recurrence in patients with short-lasting persistent AF undergoing rhythm control?

Population

100 patients with short-lasting persistent atrial fibrillation undergoing rhythm control.

Design

Cohort

Follow-up

<1 month for primary endpoint

Authors

MSMarcelle D. SmitElectrophysiology AMA. H. MaassUniversity Medical Center Groningen AJAnne Margreet de JongAmsterdam University Medical Centers

Discussion

Member takes

Implication

IL-6 may identify higher early AF recurrence risk after rhythm control; hypothesis-generating and should not yet change practice.

Key Points

To identify clinical, echocardiographic, and biomarker mechanisms associated with early arrhythmia recurrence and progression to permanent atrial fibrillation in patients with short-lasting persistent atrial fibrillation.
Evaluated 100 patients with short-lasting persistent atrial fibrillation (median total history 4.2 months) undergoing rhythm control therapy.
Assessed clinical characteristics, echocardiographic parameters, and circulating biomarkers against the primary endpoint of early recurrence (<1 month) and the secondary endpoint of progression to permanent atrial fibrillation.
Early atrial fibrillation recurrence occurred in 30% of patients (n=30) after a median of 6 days (IQR 2–14) and was independently associated with baseline log(2) interleukin-6 (adjusted HR 1.3, 95% CI 1.0–1.7, P=0.02) and smoking history (adjusted HR 3.6, 95% CI 1.2–10.9, P=0.03).
Progression to permanent atrial fibrillation occurred in 29% of patients (n=29) and was independently associated with baseline transforming growth factor-β1, left ventricular ejection fraction, and early recurrence.

Structured PICO

Are inflammatory markers like IL-6 associated with early atrial fibrillation recurrence in patients with short-lasting persistent AF undergoing rhythm control?

Population

100 patients with short-lasting persistent atrial fibrillation (median total AF history 4.2 months) undergoing rhythm control.

Intervention

Assessment of clinical factors, echocardiographic parameters, and biomarkers (including interleukin-6) as predictors of AF recurrence.

Outcome

Early AF recurrence (recurrence <1 month)

Inflammation, represented by elevated IL-6 levels, is independently associated with early recurrence of atrial fibrillation following rhythm control in patients with short-lasting persistent AF.

Cite This Study

Smit et al. (2012) studied this question.

synapsesocial.com/papers/6a0d28fbd7cdc72b86656661 https://doi.org/10.1093/europace/eur402

Topics

Atrial fibrillation Persistent AF management Myocarditis Anticoagulation in AF AF ablation outcomes

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Role of inflammation in early atrial fibrillation recurrence

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Role of inflammation in early atrial fibrillation recurrence

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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