Why the study?
Does diltiazem compared to verapamil (with or without quinidine) improve conversion to sinus rhythm in patients with chronic atrial fibrillation?
Population
30 patients with long-standing chronic atrial fibrillation
Comparison
Diltiazem vs Verapamil
Design
RCT, Randomly assigned, Double blind
Follow-up
Up to 18 days
Authors
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Diltiazem underperforms verapamil regimens for chronic AF conversion; extends evidence for verapamil-quinidine combinations in rhythm-control trials.
Does diltiazem compared to verapamil (with or without quinidine) improve conversion to sinus rhythm in patients with chronic atrial fibrillation?
Diltiazem and verapamil alone are unlikely to convert chronic atrial fibrillation to sinus rhythm, but the combination of verapamil and quinidine may be a useful pharmacologic approach.
Ochs et al. (1985) studied this question.
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