Key result
Addition of verapamil to chronic digoxin therapy significantly decreased mean resting heart rate from 87 to 72 beats/min and exercise heart rate from 151 to 106 beats/min (both p < 0.001).
Why the study?
Does the addition of verapamil to digoxin reduce heart rate in patients with chronic atrial fibrillation?
Population
10 patients (7 males, 3 females) with chronic atrial fibrillation.
Comparison
Acute intravenous verapamil followed by chronic… vs Baseline.
Design
Case_series
Follow-up
10 weeks
Authors
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May support adjunctive verapamil for rate control in chronic AF; leaves open digoxin interaction risks for prospective trials.
Does the addition of verapamil to digoxin reduce heart rate in patients with chronic atrial fibrillation?
Absolute Event Rate: 72% vs 87%
p-value: p=< 0.001
The addition of verapamil to digoxin effectively suppresses ventricular response in chronic atrial fibrillation but significantly increases serum digoxin concentrations.
Schwartz et al. (1982) studied Chronic atrial fibrillation (n=10). Verapamil vs. Baseline (chronic digoxin therapy alone) was evaluated on Mean resting heart rate by 24-hour ambulatory ECG (beats/min) (p=< 0.001). Addition of verapamil to chronic digoxin therapy significantly decreased mean resting heart rate from 87 to 72 beats/min and exercise heart rate from 151 to 106 beats/min (both p < 0.001).
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