Key result
Verapamil alone or with digoxin improves exercise and daily heart rate control over digoxin monotherapy.
Why the study?
The relative efficacy of oral verapamil alone or combined with digoxin compared to digoxin alone in chronic atrial fibrillation was unclear.
Does oral verapamil alone or in combination with digoxin improve heart rate control compared to digoxin alone in patients with chronic atrial fibrillation?
Comparison
Oral verapamil alone or verapamil plus digoxin versus digoxin alone
Design
Double-blind placebo-controlled study
Follow-up
2 weeks on each treatment regimen
Authors
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Supports verapamil regimens over digoxin monotherapy for rate control in chronic AF; confirms RCT superiority for daily activities.
RCT (n=8)
Double-blind
Does oral verapamil alone or in combination with digoxin improve heart rate control compared to digoxin alone in patients with chronic atrial fibrillation?
Verapamil alone or in combination with digoxin provides superior heart rate control during daily activities compared to digoxin alone in patients with chronic atrial fibrillation.
Pomfret et al. (1988) conducted an RCT in chronic atrial fibrillation (n=8). Verapamil alone or in combination with digoxin vs. Digoxin alone was evaluated on Heart rate at rest and during progressive load treadmill exercise, left ventricular function at rest and nocturnal heart rate. Verapamil alone (80 mg TID) or with digoxin (40 mg TID + 0.25 mg daily) was superior to digoxin alone for controlling heart rate during daily activities.
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