March 1, 1984Clinical Cardiology

Long‐term oral treatment with high doses of verapamil in lone atrial fibrillation

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Why the study?

Does long-term oral treatment with high doses of verapamil improve heart rate and symptoms in patients with lone atrial fibrillation?

Population

11 patients with lone atrial fibrillation

Design

Case_series

Authors

PJPehr JohanssonAstraZeneca (Sweden)SOS. Bertil OlssonElectrophysiology

Discussion

Member takes

Implication

High-dose verapamil is impractical for lone AF due to side effects; hypothesis-generating for symptom relief, needs prospective trials.

Structured PICO

Does long-term oral treatment with high doses of verapamil improve heart rate and symptoms in patients with lone atrial fibrillation?

Population

11 patients with lone atrial fibrillation

Intervention

Verapamil oral in gradually increasing doses from 40 mg three times a day to 320 mg three times a day, either alone or in combination with digoxin

Outcome

Heart rate, RR interval variation coefficient, and blood pressure at each dose level

While high-dose oral verapamil may relieve palpitations and occasionally restore sinus rhythm in lone atrial fibrillation, its clinical utility is severely limited by intolerable side effects.

Limitations

Side effects limit the value of this mode of treatment in the majority of patients

Cite This Study

Johansson et al. (1984) studied this question.

synapsesocial.com/papers/6a760ccb212a5a9b7b70834e https://doi.org/10.1002/clc.4960070306

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF

View Full Paper

Ask AI

Bookmark

Long‐term oral treatment with high doses of verapamil in lone atrial fibrillation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Long‐term oral treatment with high doses of verapamil in lone atrial fibrillation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider