Key result
Patient-derived models show structural features like fibrosis anchor fibrillatory rotors and convert AF to macro-reentry.
Why the study?
Do structural features and fibrosis contribute to the maintenance of fibrillatory rotors in a patient-derived computational model of the atria?
Do structural features and fibrosis contribute to the maintenance of fibrillatory rotors in a patient-derived computational model of the atria?
Patient-derived computational modeling demonstrates that structural features and fibrosis play a critical role in anchoring fibrillatory rotors, potentially converting atrial fibrillation to macro-reentry.
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May inform substrate ablation strategies in AF; extends mechanistic modeling but leaves open clinical validation.
Gonzales et al. (2014) studied Atrial fibrillation. Three-dimensional human biatrial finite element model was evaluated on Structural contributions to the maintenance of rotors in human AF and possible mechanisms of termination. A patient-derived computational model demonstrated that structural features, such as fibre discontinuities and fibrosis, can anchor fibrillatory rotors and convert fibrillation to macro-reentry.
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