Key result
Chronic atrial fibrillation was not associated with significant changes in Na, K pump current sensitivity to extracellular K+ compared to sinus rhythm (Emax 1.02 vs 1.19 pA/pF).
Absolute Event Rate: 1.02% vs 1.19%
The Na, K pump current contributes to human atrial action potential shape and refractoriness, but its sensitivity is unaltered in chronic AF, suggesting it is not involved in AF-induced electrophysiological remodeling.
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Does not implicate Na/K-ATPase in AF remodeling; leaves open other ionic targets for human studies.
Antony J. Workman (2003) studied chronic atrial fibrillation. Chronic atrial fibrillation vs. Sinus rhythm was evaluated on Maximum Na, K pump current response (Emax) to extracellular K+. Chronic atrial fibrillation was not associated with significant changes in Na, K pump current sensitivity to extracellular K+ compared to sinus rhythm (Emax 1.02 vs 1.19 pA/pF).
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