Key result
Chronic atrial fibrillation was associated with a significant reduction in the effective refractory period at physiological rates (from 203+/-16 to 104+/-15 ms, P<0.05) and attenuated rate adaptation.
Population
Enzymatically isolated atrial myocytes from 11 patients with chronic atrial fibrillation and 39 patients in…
Comparison
In vitro electrophysiological testing with… vs Myocytes from patients in sinus rhythm
Design
Preclinical
Authors
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Indicates electrical remodeling in chronic AF models; leaves open human translation and therapeutic relevance.
Observational (n=50)
Absolute Event Rate: 104% vs 203%
p-value: p=<0.05
Chronic AF is associated with attenuated adaptation of atrial single cell ERP and maximum diastolic potential to fast rates, which is not fully explained by changes in L-type calcium and transient outward potassium currents.
Antony J. Workman (2001) conducted an observational in Chronic atrial fibrillation (n=50). Chronic atrial fibrillation vs. Sinus rhythm was evaluated on Effective refractory period (ERP) at physiological rate (p=<0.05). Chronic atrial fibrillation was associated with a significant reduction in the effective refractory period at physiological rates (from 203+/-16 to 104+/-15 ms, P<0.05) and attenuated rate adaptation.
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