Key result
Chronic left ventricular myocardial infarction in dogs significantly increased the incidence and duration of pacing-induced atrial fibrillation compared to controls (P<0.05).
Why the study?
Does chronic left ventricular myocardial infarction increase vulnerability to atrial fibrillation through atrial electrical and neural remodeling in a canine model?
Population
15 dogs
Comparison
Permanent occlusion of the left anterior… vs No LAD occlusion (7 dogs, 3 with thoracotomy)
Design
Preclinical
Follow-up
8 weeks
Authors
Loading...
LV MI may heighten AF vulnerability via remote atrial remodeling in canines; extends mechanistic insights but remains hypothesis-generating for humans.
Does chronic left ventricular myocardial infarction increase vulnerability to atrial fibrillation through atrial electrical and neural remodeling in a canine model?
p-value: p=<0.05
Chronic ventricular myocardial infarction without direct atrial involvement increases atrial fibrillation vulnerability by causing heterogeneous alteration of atrial electrical restitution and sympathetic hyperinnervation.
Miyauchi et al. (2003) studied Chronic left ventricular myocardial infarction (n=15). Permanent occlusion of the left anterior descending coronary artery (MI model) vs. No LAD occlusion (controls) was evaluated on Incidence and duration of pacing-induced atrial fibrillation (p=<0.05). Chronic left ventricular myocardial infarction in dogs significantly increased the incidence and duration of pacing-induced atrial fibrillation compared to controls (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: