Prognostic accuracy of syncope clinical prediction rules in older adults in the emergency department

Study objective: The objective of this study is to evaluate the prognostic accuracy of existing rules (San Francisco Syncope Rule [SFSR], Canadian Syncope Risk Score [CSRS], and FAINT score) in older adults. Methods: This is a cohort study of adults aged ≥60 years presenting to an academic emergency department (ED) with syncope or near syncope. We used original criteria for all rules except for the FAINT score, in which N-terminal pro-brain natriuretic peptide was largely missing from the extracted data. Patients were deemed positive for each rule if classified as non-low risk. The primary outcome was the presence of 30-day serious outcome, as defined by syncope research guidelines. Sensitivity and negative likelihood ratio (NLR) were calculated with 95% confidence intervals (CIs). Results: A total of 404 ED visits (mean age of patients, 75.5 years) were included. Of these, 44 (10.9%) had a 30-day serious outcome, and 24 (5.9%) had incomplete 30-day follow-up. SFSR was positive for 280 of 380 visits with complete follow-up. Its sensitivity and NLR for predicting 30-day serious outcomes were 86.4% (95% CI, 72.0%-94.3%) and 0.53 (95% CI, 0.25-1.15), respectively. The CSRS was positive for 299 of 380 visits (sensitivity was 88.6% [95% CI, 76.4%-95.7%], and NLR was 0.50 [95% CI, 0.22-1.17]). The modified FAI(N)T score was positive for 318 of 380 visits (sensitivity was 90.9% [95% CI, 77.4%-97.0%], and NLR was 0.53 [95% CI, 0.20-1.38]). Conclusion: Existing rules are suboptimal to predict 30-day serious outcomes in older adults presenting with syncope or near syncope to the ED.