Key result
Higher CRP-to-albumin ratio in CHF correlates with elevated pulmonary artery pressure and pulmonary hypertension.
Why the study?
Inflammation can play a role in the development and progression of pulmonary hypertension, motivating an evaluation of inflammatory parameters and pulmonary artery pressure in congestive heart failure patients with and without pulmonary hypertension.
Is there a relationship between pulmonary artery pressure and inflammatory parameters in patients with congestive heart failure?
Cross-Sectional (n=80)
Is there a relationship between pulmonary artery pressure and inflammatory parameters in patients with congestive heart failure?
Effect estimate: r = 0.392
p-value: p=<0.001
In patients with congestive heart failure, the presence of pulmonary hypertension is associated with higher systemic inflammation as measured by the C-reactive protein to albumin ratio.
Background Inflammation can play a role in the development and progression of pulmonary hypertension (PHT). In this study, inflammatory parameters were compared in congestive heart failure (CHF) patients with and without PHT. The relationship between pulmonary artery pressure (PAP) and inflammatory parameters was investigated. Materials and methods Out of 80 CHF patients, 40 had PHT. The patients' age, gender, smoking status, comorbidities such as diabetes mellitus (DM) and hypertension (HT), and mortality rates were recorded. Inflammatory parameters were recorded. Results The mean age of the PHT group was 64.38 ± 9.17 and the mean age of the non-PHT group was 64.70 ± 8.99. There were 23 men and 17 women in the PHT group, and there were 21 men and 19 women in the non-PHT group. There was no significant difference between the two groups in terms of mean age and gender distribution (p = 0.874 and p = 0.653). Accordingly, the C-reactive protein to albumin ratio (CAR) value was statistically significantly higher in PHT patients (p = 0.023). The eosinophil count was found to be significantly higher in non-PHT patients (p = 0.015). Accordingly, a significant correlation was detected between CAR and PAP (r = 0.392 and p < 0.001). Conclusion In this study, the positive correlation between PAP and CAR and the significantly higher CAR value in PHT patients indicate the presence of inflammation in PHT patients. Studies on the relationship between inflammation and mortality in PHT patients may contribute more to the literature in the future.
No takes yet. Share an insight, caveat, or question.
Sabri Abuş (2024) conducted a cross-sectional in Congestive heart failure with and without pulmonary hypertension (n=80). Pulmonary hypertension (PHT) vs. No pulmonary hypertension was evaluated on Correlation between C-reactive protein to albumin ratio (CAR) and pulmonary artery pressure (PAP) (r = 0.392, p=<0.001). In congestive heart failure, the C-reactive protein to albumin ratio was higher in patients with pulmonary hypertension (p=0.023) and correlated with pulmonary artery pressure (r=0.392, p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: