Key result
Activation of protein kinase C by PMA suppressed Kv4.2 and Kv4.3 currents and native rat ventricular transient outward K+ current, an effect prevented by PKC inhibitors.
Population
Xenopus oocytes expressing Kv4.2 and Kv4.3 currents, and rat ventricular myocytes
Comparison
PKC activation using Phorbol 12-myristate… vs Preincubation with PKC inhibitors, inactive…
Design
Preclinical
Authors
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PKC activation suppresses rat ventricular Ito; extends channel regulation mechanisms in rodents but leaves open human translation.
PKC activation suppresses Kv4.2 and Kv4.3 channels, which are key components of the rat ventricular transient outward potassium current.
Nakamura et al. (1997) studied this question. PKC activation (PMA, phenylephrine, carbachol) vs. PKC inhibitors (chelerythrine) or inactive stereoisomer was evaluated on Kv4.2, Kv4.3, and native I(to) currents. Activation of protein kinase C by PMA suppressed Kv4.2 and Kv4.3 currents and native rat ventricular transient outward K+ current, an effect prevented by PKC inhibitors.
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