Key result
Overactivity of angiotensin I-converting enzyme (ACE) and the ACE D/D genotype are associated with numerous age-related, psychiatric, cardiovascular, autoimmune, and infectious diseases.
This review highlights the pleiotropic role of ACE and its D/D genotype in the pathophysiology of numerous diseases, suggesting broad therapeutic potential for ACE inhibition.
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Hypothesis-generating for ACE inhibition across diseases; should not yet change practice pending trials.
Moskowitz et al. (2004) conducted a review in Age-related diseases. Angiotensin I-converting enzyme (ACE) was evaluated. Overactivity of angiotensin I-converting enzyme (ACE) and the ACE D/D genotype are associated with numerous age-related, psychiatric, cardiovascular, autoimmune, and infectious diseases.
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